Peptide bioregulators aren’t very well known by the mainstream. They are something I have been studying for close to 10 years or so now. They have been around for a long time, first developed in the 1970’s in the Military Medical Academy in Russia, and have a lot of research behind them. Most of the research comes from Professor Vladamir Khavison. You will see peptide bioregulators sold as Khavison peptides or Khavison bioregulators at times. The peptides were initially developed on behalf of and used by the Soviet Union Military, Cosmonaut space program, and their Olympic athletes. There are 2 reasons why peptide bioregulators aren’t very well known in the west; the Russians have patents on them and have done most, if not all of the research, and the way peptide bioregulators are synthesised isn’t easy for Big Pharma to commercialize.
A peptide is a sequence of 50 amino acids or less. The bioregulators are shorter peptides, normally a chain of 2, 3, or 4 amino acids in length. The shorter the peptide sequence, the more specific its effects. For example, the heart peptide bioregulator will only interact with genes associated with the heart. Peptide bioregulators are not the same as normal/commonly known peptides like BPC-157 or TB-500. They come in capsules or tablets whereas other peptides have to be injected as they get destroyed by the stomach before they are able to be absorbed. The short sequence of amino acids allows them to be absorbed and utilised by the body even when taken orally. There are also sublingual options available. Two peptide bioregulators that are probably most well-known are Epitalon® and Thymalin®. They are well known for their ability to lengthen telomeres and extend lifespan, and more importantly, healthspan.
Bioregulators are natural substances produced in our body that try to regulate or repair systems and get us back into a healthy state. They can also be found in food; the extracts are just stronger and more precise than trying to obtain them from food sources. Peptide bioregulators are sourced from food molecules derived from young calves. Peptides are signalling molecules. They regulate the immune, nervous, and endocrine system. Peptides support many key processes in the body due to their antioxidant, antimicrobial, antibacterial, anti-inflammatory, anticarcinogenic, antitumor, and immunoregulatory characteristics. Peptide bioregulators have a molecular structure that the body is familiar with and “knows” what to do with them when ingested. They repair tissue by accelerating protein synthesis, regulating gene expression, and they directly interact with cellular DNA.
Peptide bioregulators are very specific in their actions. There is a peptide bioregulator for pretty much every gland, organ, and system of the body. Traditional peptides tend to have more systemic benefits. With peptide bioregulators, as long as you have a gland that is still functioning to some capacity, they are able to help regenerate / improve the functioning of that gland / body part. Peptide bioregulators take a little bit longer than traditional peptides to have a noticeable effect. They are more for long term regeneration / optimization of certain body systems.
The beauty of peptide bioregulators is that as the name suggests, they “regulate” / balance / modulate body systems, and don’t over stimulate or shut off the gland. For example, if someone is hypothyroid and takes the thyroid peptide bioregulator, it will help the thyroid produce more thyroid hormones but if the patient is hyperthyroid, it won’t do so. Peptide bioregulators can’t produce supraphysiological levels of hormones like hormone replacement therapy could if not monitored correctly.
Another benefit to using peptide bioregulators is there is no down regulation of receptor activity, no shutting down the production of the gland / system through negative feedback mechanisms. For example, if you take testosterone, you can shut down your natural production of testosterone and need to depend on hormone replacement to keep optimal levels. This isn’t the case with peptide bioregulators and why it would be a good idea to try and support the HPA axis, testes etc. with peptide bioregulators to maintain / optimize their natural function before starting testosterone replacement therapy. Again, all lifestyle factors should be addressed, not just taking a peptide bioregulator and thinking it is a magic bullet.
There are two main types of peptide bioregulators;
Natural peptide extracts known as cytomaxes and
Synthetic regulatory peptides also known as cytogens
Cytomaxes are bioregulators from animal tissues or organs, and are labelled A-1, A-2, A-3 etc.
Cytogens are bioregulators that are synthetically made in a lab from amino acids, and are labelled AC-2, AC-3, AC-4 etc.
There are also cytamins which are bioregulators from animal origin that also have amino acids and vitamins added to them. We will talk about cytomaxes and cytogens as that is where the research has been done and what most people have used over the years.
The cytogens (synthetic) bioregulators are faster acting, and the cytomaxes (natural) have long term effects. Typically, if someone has a disease or issue that needs urgent care, they take the cytogens (synthetic) for a couple of weeks to a month, and then begin to take the cytomaxes (naturals) for long term healing / regeneration.
Peptide bioregulators don’t need to be put into the body every single day. They have lasting effects and can be used monthly, quarterly, or even half yearly, depending on the health and goal of the individual.
If you are trying to correct an organ, gland, body system, or have some sort of disease state that you are trying to fix, you can do an intensive course which is 2 capsules per day for 30 days, 60 capsules.
After this initial 30 days, you can drop down to 2 capsules a day for 10 days, 20 caps per month, and do this monthly.
Then, once you feel you are on top of things, you can reduce your dose down to a maintenance of 2 capsules per day, for 10 days, every 3 months. Eventually, you may even go to every 6 months.
If you are younger, you would take them less often, as you age, you would do every 3 months.
A generally healthy person who wants to protect / enhance a particular system can take 2 capsules a day for 10-days and then repeat the course 6 months later.
Stacking the peptide bioregulators works better than just taking one. They are never really used alone. The best results always come when peptide bioregulators are used in combination as health is not derived from just one organ or gland. The blood vessel bioregulator Vesugen® or Ventfort® tend to be a great addition to any stack. In Russia, when Professor Khavison used them with athletes for rehabilitation and restoration, they used a combination of 6 peptide bioregulators “the best effects were from a combination of 6 peptide bioregulators, those being blood vessels, brain, thymus, cartilage, heart, and liver. This combination was recommended and used after a lot of scientific work.” They have also used them with cosmonauts and elite military forces.
In a large study on factory workers Professor Khavison saw 2.8 times less illness and morbidity compared to the control group “we had a long-term study of people working in factories. It was a large company called GAZPROM, responsible for the country’s gas supply. The participants worked in Siberia, which as you know is a harsh climate. We had 11,000 people in our study… 3000 of the 11,000 were the control group, the remainder were divided into different groups using the blood vessel, thymus and pineal peptides, or combinations of them. We found that in the peptide bioregulator groups there was less ill health and morbidity compared to the control group, in fact it was 2.8 times less. It is a massive difference, to be nearly 3 times less likely to be ill.” These workers were 35 – 60 years old.
In another study on factory workers in the Soviet Union, Professor Khavison found that workers had 2.5 times less illness and morbidity than the control group. So, results have been reproducible.
In all these studies, they only used the natural peptide bioregulators as they wanted to test safety and efficacy.
They also used peptide bioregulators with people who were trying to clean up the contamination at Chernobyl. These people were exposed to very high radiation levels, so they used higher doses. The workers mortality rate actually got lower than the average mortality rate across the country at the time.
Peptide bioregulators have also been successful at preventing retina pigmentosa from progressing to complete vision loss. It is a generic disease and there is no cure for it. Patients who suffer from this disease are told there isn’t anything they can do for it other than manage the symptoms and hopefully slow the rate of vision loss. The peptide bioregulators have helped keep vision in cases of retina pigmentosa.
You could take all 21 natural bioregulators and once and not experience any cross over effects or things like that. They are very specific in their actions as mentioned above. If you did want to take all of the peptide bioregulators, you could take 3 to 6 at a time and rotate them throughout the year so that you end up taking each of them at least twice per year.
Peptide bioregulators are very safe. They have been used in Russia for over 30 years with no negative side effects. Long term administration of doses between 100 to 1000 times the regular therapeutic doses has not reported any side effects.
Cytomaxes (natural)
A-1 | suprefort® | Pancreas peptide bioregulator |
A-2 | thyreogen® | Thyroid peptide bioregulator |
A-3 | ventfort® | Blood vessel peptide bioregulator |
A-4 | sigumir® | Cartilage peptide bioregulator |
A-5 | cerluten® | Nervous system peptide bioregulator |
A-6 | vladonix® | Thymus peptide bioregulator |
A-7 | svetinorm® | Liver peptide bioregulator |
A-8 | endoluten® | Pineal peptide bioregulator |
A-9 | pielotax® | Kidney peptide bioregulator |
A-10 | stamakort® | Stomach peptide bioregulator |
A-11 | visoluten® | Retina peptide bioregulator |
A-12 | chitomur® | Bladder peptide bioregulator |
A-13 | testoluten® | Testes peptide bioregulator |
A-14 | chelohart® | Heart peptide bioregulator |
A-15 | zhenoluten® | Ovary peptide bioregulator |
A-16 | libidon® | Prostate peptide bioregulator |
A-17 | glandokort® | Adrenal peptide bioregulator |
A-18 | gotratix® | Muscle peptide bioregulator |
A-19 | taxorest® | Lung peptide bioregulator |
A-20 | bonomarlot® | Bone marrow peptide bioregulator |
A-21 | bonthyrk® | Parathyroid peptide bioregulator |
Cytogens (synthetic)
AC-2 | Vesugen® | Blood vessel peptide bioregulator |
AC-3 | Ovagen® | Liver and gastrointestinal tract peptide bioregulator |
AC-4 | Cartalax® | Cartilage and bone tissue peptide bioregulator |
AC-5 | Pinealon® | Brain cell peptide bioregulator |
AC-6 | Crystagen® | Immune system peptide bioregulator |
AC-7 | Chonluten® | Lung and bronchial mucosa peptide bioregulator |
There are many other bioregulators such as cortagen, cortexin, vesugen, pinealon, bronchogen, thymogen, vilon, normoftal, cardiogen, epitalon, thymalin, testagen, livagen, and many more.
This is a quick overview of peptide bioregulators. We will go over individual peptide bioregulators and their benefits in the future.
References / further reading:
The Peptide Bioregulator Revolution
Peptides in the epigenic control of ageing
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